Optimization and Characterization of Biocompatible Oil-in-Water Nanoemulsion for Pesticide Delivery

详细信息    查看全文

• 作者：Zhiping Du ; Chuanxin Wang ; Xiumei Tai ; Guoyong Wang ; Xiaoying Liu
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2016
• 出版时间：March 7, 2016
• 年：2016
• 卷：4
• 期：3
• 页码：983-991
• 全文大小：509K
• ISSN：2168-0485

文摘

The formation of promising oil-in-water nanoemulsion suitable for pesticide delivery has been achieved by using methyl laurate as oil phase, and alkyl polyglycoside (APG) and polyoxyethylene 3-lauryl ether (C₁₂E₃) as mixed surfactant. Effects of APG and C₁₂E₃ mixing ratios, oil weight fraction, and total surfactant concentration on droplet size and distribution of the nanoemulsion were systematically investigated. Long-term stabilities of the nanoemulsions prepared with various surfactant mixing ratios were assessed by measuring droplet size at different time intervals; the results indicated that the main driving force for droplet size increase over time was Ostwald ripening. On this basis, a practical water-insoluble pesticide β-cypermethrin (β-CP) was incorporated into two optimized nanoemulsion systems to demonstrate potential applications. The results of dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements showed that the nanoemulsions had a nearly monodisperse droplet size distribution (PDI < 0.2) and incorporation of β-CP had no notable effect on the size and stability of the nanoemulsions. For consideration of practical application, dilution stability and spreading properties of the pesticide-loaded nanoemulsion were studied by DLS, contact angle, and dynamic surface tension, respectively. The nanoemulsion was still homogeneous after dilution, although destabilization in droplet size was observed by DLS. The results of contact angle and dynamic surface tension demonstrated the excellent spreading performance of the optimized nanoemulsion.