Facile Approach To Construct Ternary Cocktail Nanoparticles for Cancer Combination Therapy

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• 作者：Ping Huang ; Junping Ao ; Linzhu Zhou ; Yue Su ; Wei Huang ; Xinyuan Zhu ; Deyue Yan
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：July 20, 2016
• 年：2016
• 卷：27
• 期：7
• 页码：1564-1568
• 全文大小：349K
• 年卷期：0
• ISSN：1520-4812

文摘

Drug combinations have been widely used in cancer treatment. However, it remains a formidable challenge to deliver three or more therapeutic agents in one nanoparticle with a precise and tunable molar ratio because of differences in pharmacokinetics and biodistribution of various anticancer drugs. Herein, we reported a facile approach to construct ternary cocktail nanoparticles, which are composed of three different anticancer drugs, such as gemcitabine, chlorambucil, and irinotecan, through the molecular coassembly of two amphiphilic drug–drug conjugates. The component of these nanoparticles can be simply adjusted by changing the feed ratio of two amphiphilic drug–drug conjugates in the coassembly process. Without the help of any drug carriers, they can self-deliver, release three drugs synchronally, and obtain the optimal synergistic therapeutic effect. This facile strategy may open a new way for cancer combination therapy.