Single-Stimulus Dual-Drug Sensitive Nanoplatform for Enhanced Photoactivated Therapy

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• 作者：Shasha He ; Yanxin Qi ; Gaizhen Kuang ; Dongfang Zhou ; Jizhen Li ; Zhigang Xie ; Xuesi Chen ; Xiabin Jing ; Yubin Huang
• 刊名：Biomacromolecules
• 出版年：2016
• 出版时间：June 13, 2016
• 年：2016
• 卷：17
• 期：6
• 页码：2120-2127
• 全文大小：596K
• 年卷期：0
• ISSN：1526-4602

文摘

Photoactivated therapy has become a complementary and attractive modality for traditional cancer treatment. Herein, we demonstrated a novel single-stimulus dual-drug sensitive nanoplatform, Cur-loaded Dex–Pt(N₃) nanoparticles (Cur@DPNs) for enhanced photoactivated therapy. The developed Cur@DPNs could be photoactivated by UVA light to simultaneously generate instant reactive oxygen species from Cur for fast photodynamic therapy and release lasting Pt(II) from Pt(N₃) for long-acting photochemotherapy. Compared with small free drugs and individual photoactivated therapy, Cur@DPNs exhibited enhanced photoactivated cytotoxicity and in vivo antitumor efficacy with low systemic toxicity accompanied. Therefore, the single-stimulus dual-drug sensitive nanoplatform is convinced to be a promising strategy for multidrug delivery, site-selective and combinational photoactivated therapy in the near future.