Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System

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• 作者：Xiang Li ; Qiuxiang Yin ; Meijing Zhang ; Baohong Hou ; Ying Bao ; Junbo Gong ; Hongxun Hao ; Yongli Wang ; Jingkang Wang ; Zhao Wang
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2016
• 出版时间：July 13, 2016
• 年：2016
• 卷：55
• 期：27
• 页码：7484-7492
• 全文大小：455K
• 年卷期：0
• ISSN：1520-5045

文摘

The crystallization process of erythromycin ethylsuccinate in a tetrahydrofuran–water system was investigated. Results show that oiling-out occurs under several conditions; hence, a phase diagram with a liquid–liquid equilibrium area was established experimentally. For improved understanding of oiling-out crystallization, a series of in situ tools, including focused beam reflectance measurement, attenuated total reflectance Fourier transform infrared spectroscopy, and particle vision measurement, were applied to monitor the oiling-out phenomenon and the subsequent nucleation of erythromycin ethylsuccinate. SEM images were employed to analyze the influence of oiling-out on the properties of the final crystals. The nucleation mechanism of erythromycin ethylsuccinate differs significantly depending on the location of the line of operation. The combination of cooling method and antisolvent crystallization can be achieved with fundamental data of the phase diagram to suppress the oiling-out phenomenon and obtain crystal products with high quality. The ternary phase diagram is of great importance in the process design of antisolvent crystallization for an oiling-out system.