Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

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• 作者：Jie Pan ; Bethany I. Harriss ; Chi-Fai Chan ; Lijun Jiang ; Tik-Hung Tsoi ; Nicholas J. Long ; Wing-Tak Wong ; Wai-Kwok Wong ; Ka-Leung Wong
• 刊名：Inorganic Chemistry
• 出版年：2016
• 出版时间：July 18, 2016
• 年：2016
• 卷：55
• 期：14
• 页码：6839-6841
• 全文大小：220K
• 年卷期：0
• ISSN：1520-510X

文摘

A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. ⁶⁸GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.