Soy Isoflavonoid Aglycons Genistein and Daidzein Do Not Increase the Cytochrome P-450 Content of the Liver Microsomes of Mice

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• 作者：Taro Kishida ; Kunitaka Nashiki ; Toru Izumi ; and Kiyoshi Ebihara
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2000
• 出版时间：September 2000
• 年：2000
• 卷：48
• 期：9
• 页码：3872 - 3875
• 全文大小：37K
• 年卷期：v.48,no.9(September 2000)
• ISSN：1520-5118

文摘

Mice (4-week-old, male ddy) were fed four isonitrogenic diets for 21 days: purified diet (C diet);fermented soybean (400 mg of soy isoflavonoids/kg; FSB); fermented soybean extract (400 mg ofsoy isoflavonoid aglycones/kg; FSBE); C with indole-3 carbinol (I3C) (2500 mg of I3C/kg; I3C). TheI3C and FSB diets significantly increased the cytochrome P-450 content of hepatic microsomes incomparison with the C diet, while the FSBE diet did not. Other mice were fed seven diets for 21days: C; C with 100 mg or 200 mg of genistein, 100 mg or 200 mg of daidzein, or 100 mg of genistein+ 100 mg of daidzein/kg; I3C diet. Genistein and daidzein did not change the liver cytochromeP-450 content. There was no synergistic effect of the combined feeding of genistein and daidzein.The increase in the cytochrome P-450 content with the FSB diet depends on chemicals other thangenistein and daidzein. Genistein and daidzein do not induce cytochrome P-450.Keywords: Fermented soybean; genistein; daidzein; P-450; mice