DNA Photocleavage by Non-innocent Ligand-Based Ru(II) Complexes

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• 作者：Yangyang Zhang ; Qianxiong Zhou ; Yue Zheng ; Ke Li ; Guoyu Jiang ; Yuanjun Hou ; Baowen Zhang ; Xuesong Wang
• 刊名：Inorganic Chemistry
• 出版年：2016
• 出版时间：May 2, 2016
• 年：2016
• 卷：55
• 期：9
• 页码：4296-4300
• 全文大小：317K
• 年卷期：0
• ISSN：1520-510X

文摘

In this work, we demonstrate for the first time that [Ru(bpy)₂(R-OQN)]⁺ complexes (bpy = 2,2′-bipyridine, R-OQN = 5-chloro-8-oxyquinolate or 5-bromo-8-oxyquinolate) are able to generate hydroxyl radicals and cleave DNA effectively upon visible light irradiation. The potent electron-donating ability of the R-OQN-based non-innocent ligands gives the complexes a high reducing capability, favoring the generation of superoxide anion radicals from which hydroxyl radicals may be generated. More interestingly, halogen substitution plays an important role. When the 5-Cl- or 5-Br-8-oxyquinolate ligand is replaced by 8-oxyquinolate or 5-CH₃-8-oxyquinolate, the corresponding complexes lose their hydroxyl radical-generation and DNA photocleavage abilities. These findings open new applications for the non-innocent ligand-based Ru(II) complexes in the fields of biology and medicine, such as in photodynamic therapy (PDT).