Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila

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• 作者：Xiao-xuan Xin ; Yong Chen ; Di Chen ; Fa Xiao ; Laurence D. Parnell ; Jing Zhao ; Liang Liu ; Jose M. Ordovas ; Chao-Qiang Lai ; Li-rong Shen
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：July 27, 2016
• 年：2016
• 卷：64
• 期：29
• 页码：5803-5812
• 全文大小：552K
• 年卷期：0
• ISSN：1520-5118

文摘

The major royal-jelly proteins (MRJPs) are the main constituents responsible for the specific physiological role of royal jelly (RJ) in honeybees. Male and female Drosophila flies were fed diets containing either no MRJPs (A) or casein (B) at 1.25% (w/w) of diet or MRJPs at 1.25% (C), 2.50% (D), or 5.00% (E). Diets B, C, D, and E increased mean lifespan by 4.3%, 9.0%, 12.4%, and 13.9% in males and by 5.8%, 9.7%, 20.0%, and 11.8% in females in comparison to results from diet A, respectively. The diet supplemented with 2.50% MRJPs seems to have the optimal dose to improve both physiological and biochemical measures related to aging in both sexes. Interestingly, lifespan extension by MRJPs in Drosophila was positively associated with feeding and fecundity and up-regulation of copper and zinc–superoxide dismutase (CuZn–SOD) and the Egfr-mediated signaling pathway. This study provides strong evidence that MRJPs are important components of RJ for prolonging lifespan in Drosophila.