Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B

详细信息    查看全文

• 作者：Baojian Guo ; Chengyou Zheng ; Wei Cai ; Jiehong Cheng ; Hongyu Wang ; Haitao Li ; Yewei Sun ; Wei Cui ; Yuqiang Wang ; Yifan Han ; Simon Ming-Yuen Lee ; Zaijun Zhang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：July 6, 2016
• 年：2016
• 卷：64
• 期：26
• 页码：5324-5333
• 全文大小：506K
• 年卷期：0
• ISSN：1520-5118

文摘

Chrysin, a flavonoid compound existing in several plants, is applied as a dietary supplement because of its beneficial effects on general human health and alleviation of neurological disorders. However, mechanisms underlying neuroprotection of chrysin has not been fully elucidated, and the effects of chrysin on the Parkinson’s disease (PD) model in vivo have not been investigated. It is here shown that chrysin protects primary granular neurons against 1-methyl-4-phenylpyridinium ion insult via antiapoptosis by reversing the dysregulated expression of Bcl-2, Bax, and caspase 3. The mechanisms also involved activating transcriptional factor myocyte enhancer factor 2D (MEF2D) via regulation of AKT-GSK3β signaling. In this in vivo model of PD, chrysin rescued the dopaminergic neurons loss and alleviated the decrease in dopamine level induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Moreover, chrysin markedly inhibited monoamine oxidase-B activity in vitro and in vivo. In conclusion, chrysin exerts beneficial effects to PD, possibly through multitarget mechanisms including antineuronal apoptosis, activation of the AKT-GSK3β/MEF2D pathway, and inhibition of the MAO-B activity.