New Fusaric Acid Derivatives from the Endophytic Fungus Fusarium oxysporum and Their Phytotoxicity to Barley Leaves

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• 作者：Shuai Liu ; Haofu Dai ; Raha S. Orfali ; Wenhan Lin ; Zhen Liu ; Peter Proksch
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：April 27, 2016
• 年：2016
• 卷：64
• 期：16
• 页码：3127-3132
• 全文大小：274K
• 年卷期：0
• ISSN：1520-5118

文摘

Chemical investigation of the endophytic fungus Fusarium oxysporum isolated from fruits of Drepanocarpus lunatus afforded eight new fusaric acid derivatives, fusaricates A–G, 1–7, and 10-hydroxy-11-chlorofusaric acid, 8, along with four known compounds. Their structures were elucidated by one- and two-dimensional NMR as well as MS data and by comparison with the literature. The absolute configurations of fusaricates C–E, 3–5, were determined using chiral GC-MS. Fusaricates A–G, 1–7, represent the first examples of fusaric acid linked to a polyalcohol moiety via an ester bond. All isolated fusaric acid derivatives 1–8 showed significant phytotoxicity to leaves of barley.