Compartmentalized Droplets for Continuous Flow Liquid–Liquid Interface Catalysis

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• 作者：Ming Zhang ; Lijuan Wei ; Huan Chen ; Zhiping Du ; Bernard P. Binks ; Hengquan Yang
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：August 17, 2016
• 年：2016
• 卷：138
• 期：32
• 页码：10173-10183
• 全文大小：839K
• 年卷期：0
• ISSN：1520-5126

文摘

To address the limitations of batch organic–aqueous biphasic catalysis, we develop a conceptually novel method termed Flow Pickering Emulsion, or FPE, to process biphasic reactions in a continuous flow fashion. This method involves the compartmentalization of bulk water into micron-sized droplets based on a water-in-oil Pickering emulsion, which are packed into a column reactor. The compartmentalized water droplets can confine water-soluble catalysts, thus “immobilizing” the catalyst in the column reactor, while the interstices between the droplets allow the organic (oil) phase to flow. Key fundamental principles underpinning this method such as the oil phase flow behavior, the stability of compartmentalized droplets and the confinement capability of these droplets toward water-soluble catalysts are experimentally and theoretically investigated. As a proof of this concept, case studies including a sulfuric acid-catalyzed addition reaction, a heteropolyacid-catalyzed ring opening reaction and an enzyme-catalyzed chiral reaction demonstrate the generality and versatility of the FPE method. Impressively, in addition to the excellent durability, the developed FPE reactions exhibit up to 10-fold reaction efficiency enhancement in comparison to the existing batch reactions, indicating a unique flow interface catalysis effect. This study opens up a new avenue to allow conventional biphasic catalysis reactions to access more sustainable and efficient flow chemistry using an innovative liquid–liquid interface protocol.