Simple and Clean Photoinduced Aromatic Trifluoromethylation Reaction

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• 作者：Lu Li ; Xiaoyue Mu ; Wenbo Liu ; Yichen Wang ; Zetian Mi ; Chao-Jun Li
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：May 11, 2016
• 年：2016
• 卷：138
• 期：18
• 页码：5809-5812
• 全文大小：389K
• 年卷期：0
• ISSN：1520-5126

文摘

We describe a simple, metal- and oxidant-free photochemical strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes under either ultraviolet or visible light irradiation. We demonstrated that photoexcited aliphatic ketones, such as acetone and diacetyl, can be used as promising low-cost radical initiators to generate CF₃ radicals from sodium triflinate efficiently. The broad utility of this strategy and its benefit to medicinal chemistry are demonstrated by the direct trifluoromethylation of unprotected bidentate chelating ligand, xanthine alkaloids, nucleosides, and related antiviral drug molecules.