Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla

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• 作者：Yao-Bo Zeng ; Xiao-Ling Liu ; Yi Zhang ; Chuang-Jun Li ; Dong-Ming Zhang ; Yao-Zong Peng ; Xing Zhou ; Hong-Fei Du ; Chun-Bing Tan ; Yu-Yu Zhang ; Da-Jian Yang
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：August 26, 2016
• 年：2016
• 卷：79
• 期：8
• 页码：2032-2038
• 全文大小：360K
• 年卷期：0
• ISSN：1520-6025

文摘

Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (1–3), five 1,2-dimethyl cantharimide-type derivatives (4, 5, 7–9), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (10–12), together with seven known cantharimides (6, 13–18), were isolated from Mylabis phalerata Palla. The planar structures and absolute configurations of compounds 1–14 were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds 6, 15, 16, and 18 were found to be potent inhibitors of HBV virus, with IC₅₀ values of 62, 42, 58, and 19 μM.