Di-nor- and 17-nor-pimaranes from Icacina trichantha

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• 作者：Brian Guo ; Monday M. Onakpa ; Xiao-Jun Huang ; Bernard D. Santarsiero ; Wei-Lun Chen ; Ming Zhao ; Xiao-Qi Zhang ; Steven M. Swanson ; Joanna E. Burdette ; Chun-Tao Che
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：July 22, 2016
• 年：2016
• 卷：79
• 期：7
• 页码：1815-1821
• 全文大小：327K
• 年卷期：0
• ISSN：1520-6025

文摘

Six new pimarane derivatives, including two di-nor-pimaranes (1, 2), two 17-nor-pimaranes (3, 4), and two 17-nor-(9β-H)-pimaranes (5, 6), were isolated from the tuber of Icacina trichantha. Their structures were elucidated based on spectroscopic and HRMS data. The absolute configurations of 1 and 5 were determined by single-crystal X-ray diffraction, and that of 2 was established by electronic circular dichroism data analysis. Compound 3 possesses a unique C-20 acetal moiety. This is the first report of the isolation of di-nor-(9β-H)-pimarane derivatives from Icacina plants. Compounds 5 and 6 showed moderate cytotoxicity against MDA-MB-435, MDA-MB-231, and OVCAR3 cell lines, with IC₅₀ values of 2.91–7.60 and 1.48–3.23 μM, respectively.