Hypocriols A–F, Heterodimeric Botryane Ethers from Hypocrea sp., an Insect-Associated Fungus

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• 作者：Fengxia Ren ; Shuaiming Zhu ; Bo Wang ; Li Li ; Xingzhong Liu ; Ruibin Su ; Yongsheng Che
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：July 22, 2016
• 年：2016
• 卷：79
• 期：7
• 页码：1848-1856
• 全文大小：439K
• 年卷期：0
• ISSN：1520-6025

文摘

The new heterodimeric botryane ethers hypocriols A–F (1–6) and the known compounds 4β-acetoxy-9β,10β,15α-trihydroxyprobotrydial (7), dihydrobotrydial (8), 10-oxodehydrodihydrobotrydial (9), and dehydrobotrydienol (10) were isolated from the solid cultures of an insect-associated fungus Hypocrea sp. The structures of 1–6 were elucidated primarily by NMR experiments. The absolute configuration of 1 was assigned using the modified Mosher method and electronic circular dichroism (ECD) calculations, whereas those for 3–5, and 2 and 6 were deduced via ECD calculations and circular dichroism data, respectively. Compounds 1–6 appear to be the first heterodimeric botryane ethers and showed antiproliferative effects against a small panel of four human tumor cell lines.