Antiproliferative and Anti-inflammatory Withanolides from Physalis angulata

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• 作者：Cheng-Peng Sun ; Chong-Yue Qiu ; Ting Yuan ; Xiu-Fang Nie ; Hong-Xin Sun ; Qian Zhang ; Hui-Xiang Li ; Li-Qin Ding ; Feng Zhao ; Li-Xia Chen ; Feng Qiu
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：June 24, 2016
• 年：2016
• 卷：79
• 期：6
• 页码：1586-1597
• 全文大小：512K
• 年卷期：0
• ISSN：1520-6025

文摘

Sixteen new withanolides, physangulatins A–N (1–14) and withaphysalins Y and Z (15 and 16), as well as 12 known analogues, were isolated from the stems and leaves of Physalis angulata L. Their structures were established using extensive spectroscopic data analyses. The absolute configurations of 1 and 9 were assigned via X-ray crystallography. The isolated compounds were tested for their antiproliferative effects against human prostate cancer cells (C4-2B and 22Rvl), human renal carcinoma cells (786-O, A-498, and ACHN), and human melanoma cells (A375-S2), as well as inhibitory effects on NO production induced by LPS in macrophages. Compounds 9, 17, 20, 21, 25, and 27 showed antiproliferative effects against all tested cancer cells, with IC₅₀ values of 0.18–7.43 μM. Compounds 3–5, 9–11, 17, 20–22, 24, 25, and 27 displayed inhibitory effects against NO production, with IC₅₀ values of 1.36–11.59 μM.