Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

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• 作者：George R. Pettit ; Qinghua Ye ; Delbert L. Herald ; John C. Knight ; Fiona Hogan ; Noeleen Melody ; Venugopal J. R. V. Mukku ; Dennis L. Doubek ; Jean-Charles Chapuis
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：June 24, 2016
• 年：2016
• 卷：79
• 期：6
• 页码：1598-1603
• 全文大小：375K
• 年卷期：0
• ISSN：1520-6025

文摘

The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1–4) were isolated, accompanied by four previously known triterpenes (5–8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1–8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.