Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity

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• 作者：Luo-Sheng Wan ; Rui Chu ; Xing-Rong Peng ; Guo-Lei Zhu ; Mu-Yuan Yu ; Lei Li ; Lin Zhou ; Shuang-Yang Lu ; Jin-Run Dong ; Zhi-Run Zhang ; Yan Li ; Ming-Hua Qiu
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：June 24, 2016
• 年：2016
• 卷：79
• 期：6
• 页码：1628-1634
• 全文大小：305K
• 年卷期：0
• ISSN：1520-6025

文摘

Twelve new diterpenoids based on two rare skeletal types, namely, paralianones A–D (1–4) and pepluanols A–H (5–12), along with five known compounds, were isolated from an acetone extract of Euphorbia peplus. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. These diterpenoids were evaluated for potential anti-inflammatory activity in a lipopolysaccharide-stimulated mouse macrophage cellular model. Compounds 3, 4, 11, 13, and 16 displayed moderate inhibitory effects on NO inhibition, with IC₅₀ values ranging from 29.9 to 38.3 μM.