Tadehaginosides A–J, Phenylpropanoid Glucosides from Tadehagi triquetrum, Enhance Glucose Uptake via the Upregulation of PPARγ and GLUT-4 in C2C12 Myotubes

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• 作者：Xiaopo Zhang ; Changyu Chen ; Yonghui Li ; Deli Chen ; Lin Dong ; Wei Na ; Chongming Wu ; Junqing Zhang ; Youbin Li
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：May 27, 2016
• 年：2016
• 卷：79
• 期：5
• 页码：1249-1258
• 全文大小：495K
• 年卷期：0
• ISSN：1520-6025

文摘

Ten new phenylpropanoid glucosides, tadehaginosides A–J (1–10), and the known compound tadehaginoside (11) were obtained from Tadehagi triquetrum. These phenylpropanoid glucosides were structurally characterized through extensive physical and chemical analyses. Compounds 1 and 2 represent the first set of dimeric derivatives of tadehaginoside with an unusual bicyclo[2.2.2]octene skeleton, whereas compounds 3 and 4 contain a unique cyclobutane basic core in their carbon scaffolds. The effects of these compounds on glucose uptake in C2C12 myotubes were evaluated. Compounds 3–11, particularly 4, significantly increased the basal and insulin-elicited glucose uptake. The results from molecular docking, luciferase analyses, and ELISA indicated that the increased glucose uptake may be due to increases in peroxisome proliferator-activated receptor γ (PPARγ) activity and glucose transporter-4 (GLUT-4) expression. These results indicate that the isolated phenylpropanoid glucosides, particularly compound 4, have the potential to be developed into antidiabetic compounds.