Eucarobustols A–I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta

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• 作者：Yang Yu ; Li-She Gan ; Sheng-Ping Yang ; Li Sheng ; Qun-Fang Liu ; Shao-Nong Chen ; Jia Li ; Jian-Min Yue
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：May 27, 2016
• 年：2016
• 卷：79
• 期：5
• 页码：1365-1372
• 全文大小：437K
• 年卷期：0
• ISSN：1520-6025

文摘

Nine new conjugates of sesquiterpenoids and acylphloroglucinols, named eucarobustols A–I (1–9), as well as 11 known analogues were isolated from the leaves of Eucalyptus robusta. The sesquiterpenoid motifs furnishing the new conjugates included four structural types of aristolane (1 and 2), guaiane (3), eudesmane (4), and aromadendrane (5–9) moieties. Compounds 1 and 2 were found to represent the first examples of conjugates of aristolane and acylphloroglucinol units. In turn, compound 3 features a new coupling model of guaiane and acylphloroglucinol via the C-4–C-7′ bond. Compounds 1, 7, and 9 showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC₅₀ values of 1.3, 1.8, and 1.6 μM, respectively.