Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities

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• 作者：Guanqun Zhan ; Junfei Zhou ; Rong Liu ; Tingting Liu ; Guoli Guo ; Jianping Wang ; Ming Xiang ; Yongbo Xue ; Zengwei Luo ; Yonghui Zhang ; Guangmin Yao
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：760-766
• 全文大小：350K
• 年卷期：0
• ISSN：1520-6025

文摘

Sixteen new alkaloids belonging to the galanthamine (1–6), plicamine (7–14), and secoplicamine (15 and 16) classes, together with eight known analogues (17–24), were isolated from Zephyranthes candida. The structures of 1–16 were determined by extensive spectroscopic analyses, and the absolute configurations of 1, 2, 7, 8, and 17 were confirmed by single-crystal X-ray diffraction analysis. The orientation of 3-OCH₃ in N-methyl-5,6-dihydroplicane (22) was revised. Alkaloids 3, 12–14, and 18–21 exhibited anti-acetylcholinesterase activities with IC₅₀ values ranging from 0.48 to 168.7 μM. Compounds 10–12, 14, and 16 showed in vitro anti-inflammatory activities with IC₅₀ values ranging from 7.50 to 23.55 μM.