Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa

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• 作者：Guoyong Luo ; Qi Ye ; Baowen Du ; Fei Wang ; Guo-lin Zhang ; Yinggang Luo
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：886-893
• 全文大小：424K
• 年卷期：0
• ISSN：1520-6025

文摘

Five new iridoid glucoside derivatives (1–5), three new diterpenoids (7, 12, and 15), and 11 known compounds were isolated from the aqueous EtOH extract of Caryopteris glutinosa. Cell-based estrogen biosynthesis assays indicated that caryopteriside C (3) and caryopterisoid B (12) promote the biosynthesis of estrogen E2, with EC₅₀ values of 11.1 and 8.0 μM, respectively, in human ovarian granulosa-like KGN cells via upregulating the expression of aromatase.