Minor Pyranonaphthoquinones from the Apothecia of the Lichen Ophioparma ventosa

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• 作者：Pierre Le Pogam ; Anne-Cécile Le Lamer ; Bandi Siva ; Béatrice Legouin ; Arnaud Bondon ; Jérôme Graton ; Denis Jacquemin ; Isabelle Rouaud ; Solenn Ferron ; Walter Obermayer ; K. Suresh Babu ; Joël Boustie
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：1005-1011
• 全文大小：352K
• 年卷期：0
• ISSN：1520-6025

文摘

Four new quinonoid naphthopyranones, ophioparmin (1), 4-methoxyhaemoventosins (2a and 2b), and 4-hydroxyhaemoventosin (3), together with anhydrofusarubin lactone (4) and haemoventosin (5) were isolated from the fruiting bodies of Ophioparma ventosa, a crustose lichen. Their structures were determined by spectroscopic analyses, and the absolute configurations of 1 and 2 were elucidated through experimental and calculated electronic circular dichroism analyses. Compounds 1, 2, and 5 exhibited moderate to strong antioxidant activities. The main pigment haemoventosin exhibited significant cytotoxicity toward a panel of nine cell lines.