Eremophilane-Type Sesquiterpenoids from an Acremonium sp. Fungus Isolated from Deep-Sea Sediments

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• 作者：Zhongbin Cheng ; Jingjun Zhao ; Dong Liu ; Peter Proksch ; Zhimin Zhao ; Wenhan Lin
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：1035-1047
• 全文大小：609K
• 年卷期：0
• ISSN：1520-6025

文摘

Chemical examination of an EtOAc extract of a cultured Acremonium sp. fungus from deep-sea sediments resulted in the isolation of 15 new eremophilane-type sesquiterpenoids, namely, acremeremophilanes A–O (1–15), together with seven known analogues. The structures of new compounds were determined through extensive spectroscopic analyses, in association with chemical conversions and ECD calculations for configurational assignments. The PKS-derived 4-hexenoic acid unit in 2–6 is rarely found in nature. All compounds were evaluated for inhibitory effects toward nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compounds 2–6 and 14 exhibited inhibitory effects with IC₅₀ values ranging from 8 to 45 μM.