Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea

详细信息    查看全文

• 作者：Weiping Yuan ; Shimiao Cheng ; Weitao Fu ; Min Zhao ; Xiubao Li ; Yuepiao Cai ; Jianyong Dong ; Kexin Huang ; Kirk R. Gustafson ; Pengcheng Yan
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：1124-1131
• 全文大小：354K
• 年卷期：0
• ISSN：1520-6025

文摘

Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and the two new cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (4) and (S)-4-hydroxy-5-methylene-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (5), were isolated from a South China Sea collection of the soft coral Sinularia verruca. Eleven previously described marine metabolites (7–15, 18, and 19) were also obtained as well as three new EtOH-adduct artifacts (6, 16, and 17). The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 4, 5, and 16 showed protection against the cytopathic effects of HIV-1 infection with EC₅₀ values of 5.8–34 μM, and 4, 6, and 16 exhibited inhibition against LPS-induced NO production with IC₅₀ values of 24–28 μM.