Copper-Catalyzed Oxirane-Opening Reaction with Aryl Iodides and Se Powder

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• 作者：Lin Min ; Ge Wu ; Miaochang Liu ; Wenxia Gao ; Jinchang Ding ; Jiuxi Chen ; Xiaobo Huang ; Huayue Wu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：81
• 期：17
• 页码：7584-7590
• 全文大小：375K
• 年卷期：0
• ISSN：1520-6904

文摘

Using Se powder as the selenating reagent, the copper-catalyzed double C–Se cross-coupling of aryl iodides, epoxides, and elemental selenium has been developed. This strategy provides a straightforward approach to the synthesis of β-hydroxy phenylselenides with excellent regioselectivity of the ring opening reaction. This process proceeds in generally good yields and is compatible with a broad range of functional groups.