Solvent-Free DABCO-Mediated [3 + 2] Cycloadditions of Donor–Acceptor Cyclopropanes with Aldehydes: Strategy for Synthesis of Fully Substituted Furans

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• 作者：Jiaming Liu ; Weijian Ye ; Xushun Qing ; Cunde Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：81
• 期：17
• 页码：7970-7976
• 全文大小：367K
• 年卷期：0
• ISSN：1520-6904

文摘

DABCO-mediated [3 + 2] cycloadditions of donor–acceptor cyclopropanes with aldehydes under solvent-free conditions have been developed for the preparation of fully substituted furans which are a wide range of structurally interesting and pharmacologically significant compounds. The reaction appears to be general for a variety of 1-cyanocyclopropane-1-carboxylates and aldehydes and tolerates the presence of aromatic moieties with electron-withdrawing and electron-donating substituents.