Regioselective 2,2,2-Trifluoroethylation of Imidazopyridines by Visible Light Photoredox Catalysis

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• 作者：Mei Zhu ; Xin Han ; Weijun Fu ; Zhiqiang Wang ; Baoming Ji ; Xin-Qi Hao ; Mao-Ping Song ; Chen Xu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：81
• 期：16
• 页码：7282-7287
• 全文大小：356K
• 年卷期：0
• ISSN：1520-6904

文摘

A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with excellent regioselectivities and high functional group tolerance.