Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides

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• 作者：De-Long Kong ; Liang Cheng ; Tao Yue ; Hong-Ru Wu ; Wei-Chun Feng ; Dong Wang ; Li Liu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：81
• 期：13
• 页码：5337-5344
• 全文大小：482K
• 年卷期：0
• ISSN：1520-6904

文摘

A highly efficient and facile cobalt-catalyzed C–H activation and peroxidation of 2-oxindoles was reported, which provides a new pathway for the synthesis of biologically active 3-peroxy-2-oxindoles from readily available starting materials in excellent chemical yields. The resulting products could be further transformed into various substituted 3-peroxyoxindoles in good to excellent yields. The developed method has been successfully applied to the synthesis of the natural product (±)-N-[2-(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)ethyl]acetamide.