Pd-Catalyzed Coupling of γ-C(sp3)–H Bonds of Oxalyl Amide-Protected Amino Acids with Heteroaryl and Aryl Iodides

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• 作者：Jian Han ; Yongxiang Zheng ; Chao Wang ; Yan Zhu ; Zhi-Bin Huang ; Da-Qing Shi ; Runsheng Zeng ; Yingsheng Zhao
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：81
• 期：13
• 页码：5681-5689
• 全文大小：444K
• 年卷期：0
• ISSN：1520-6904

文摘

Pd-catalyzed regioselective coupling of γ-C(sp³)–H bonds of oxalyl amide-protected amino acids with heteroaryl and aryl iodides is reported. A wide variety of iodides are tolerated, giving the corresponding products in moderate to good yields. Various oxalyl amide-protected amino acids were compatible in this C–H transformation, thus representing a practical method for constructing non-natural amino acid derivatives.