Silver-Catalyzed Difluoroamidation of Activated Alkenes for the Construction of Difluorinated 3,3-Disubstituted Oxindoles

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• 作者：Chao Wang ; Qiao Chen ; Quanping Guo ; Hong Liu ; Zhaoqing Xu ; Yubing Liu ; Mengran Wang ; Rui Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：81
• 期：13
• 页码：5782-5788
• 全文大小：462K
• 年卷期：0
• ISSN：1520-6904

文摘

A AgOAc catalyzed difunctionalization of activated alkenes through a difluoroamidic radical addition to afford difluoroamidated 3,3-disubstituted oxindoles has been developed. Various functional groups were well tolerated. Moreover, the product could be efficiently derived to the corresponding difluorofunctionalized alcohol, ketone, and ester in high yields. The mechanistic studies revealed that a radical pathway was involved in the transformation.