Ni(II)-Catalyzed C(sp2)–H Alkynylation/Annulation with Terminal Alkynes under an Oxygen Atmosphere: A One-Pot Approach to 3-Methyleneisoindolin-1-one

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• 作者：Xin-Xiang Zheng ; Cong Du ; Xue-Mei Zhao ; Xinju Zhu ; Jian-Feng Suo ; Xin-Qi Hao ; Jun-Long Niu ; Mao-Ping Song
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：81
• 期：10
• 页码：4002-4011
• 全文大小：584K
• 年卷期：0
• ISSN：1520-6904

文摘

A nickel(II)-catalyzed alkynylation/annulation cascade via double C–H cleavage has been successfully achieved. This methodology adopted a removable N,O-bidentate directing group with a broad range of amide substrates and terminal alkynes being well tolerated. The catalytic system allowed for atom-economical and environmentally benign one-pot construction of the corresponding 3-methyleneisoindolin-1-one derivatives using O₂ as the external oxidant.