Silver(I)-Catalyzed Tandem Sigamatropic Rearrangement/1,3-H Shift/6π Aza-electrocyclization of N-Propargylic Hydrazones: A Mild Synthetic Route to 1,6-Dihydropyridazines

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• 作者：Zong-Cang Ding ; Lu-Chuan Ju ; Ying Yang ; Xiao-Ming An ; Yun-Bing Zhou ; Ren-Hao Li ; Hai-Tao Tang ; Cheng-Ke Ding ; Zhuang-Ping Zhan
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：81
• 期：9
• 页码：3936-3941
• 全文大小：378K
• 年卷期：0
• ISSN：1520-6904

文摘

A highly efficient AgOTf catalyzed [3,3] sigmatropic rearrangement/1,3-H shift/6π aza-electrocyclization cascade reaction of N-propargylic hydrazones has been developed. This method provides a new mild synthetic route to various polysubstituted 1,6-dihydropyridazines including the 3-CF₃-substituted ones with high selectivity.