Cu-Catalyzed Multicomponent Reaction of Styrenes, Perfluoroalkyl Halide, Alcohol, and tert-Butyl Hydroperoxide: One-Pot Synthesis of (Z)-β-Alkoxyperfluoroalkenone

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• 作者：Qiang Luo ; Chunmei Liu ; Jingjing Tong ; Ying Shao ; Wenyu Shan ; Hanghang Wang ; Hao Zheng ; Jiang Cheng ; Xiaobing Wan
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：81
• 期：8
• 页码：3103-3111
• 全文大小：513K
• 年卷期：0
• ISSN：1520-6904

文摘

An efficient synthesis of Z-perfluoroalkyl-substituted enones by a multicomponent reaction strategy has been described. A variety of elusive perfluoroalkylated enones are furnished under mild reaction conditions in good yields with unique chemo- and stereoselectivity. A sequence of radical-mediated Kornblum–DeLaMare reaction, Michael addition, and HF elimination is proposed for the mechanism.