Construction of Substituted Benzenes via Pd-Catalyzed Cross-Coupling/Cyclization Reaction of Vinyl Halides and Terminal Alkynes

详细信息    查看全文

• 作者：Meihua Xie ; Shengke Wang ; Jun Wang ; Kuang Fang ; Changqing Liu ; Chao Zha ; Jing Jia
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：81
• 期：8
• 页码：3329-3334
• 全文大小：427K
• 年卷期：0
• ISSN：1520-6904

文摘

A tandem Sonogashira coupling/cyclization/aromatization sequence of β-halo vinyl sulfones/ketones with terminal alkynes has been developed for the construction of benzene rings. Polysubstituted functionalized benzenes containing a sulfonyl or an acyl group could be obtained in up to 95% yield.