Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation

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• 作者：Yizhou Dong ; Weiheng Wang ; Omid Veiseh ; Eric A. Appel ; Kun Xue ; Matthew J. Webber ; Benjamin C. Tang ; Xi-Wen Yang ; Gordon C. Weir ; Robert Langer ; Daniel G. Anderson
• 刊名：Langmuir
• 出版年：2016
• 出版时间：August 30, 2016
• 年：2016
• 卷：32
• 期：34
• 页码：8743-8747
• 全文大小：294K
• 年卷期：0
• ISSN：1520-5827

文摘

Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid–glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10–60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.