Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles

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• 作者：Yaoming Wan ; Zuoning Wang ; Jing Sun ; Zhibo Li
• 刊名：Langmuir
• 出版年：2016
• 出版时间：August 2, 2016
• 年：2016
• 卷：32
• 期：30
• 页码：7512-7518
• 全文大小：415K
• 年卷期：0
• ISSN：1520-5827

文摘

Peptide hydrogels with high stability in different media are of great interest in biomedical applications. In this paper, we report an easy, fast, and scalable method for preparing a family of nonionic peptide amphiphiles (PAs) obtained by direct aminolysis of alkyl-oilgo(γ-benzyl-l-glutamate) samples, which were synthesized via the alkyl amine-initiated sequence ring-opening reaction of α-amino acid N-carboxyanhydrides. One great advantage of this method is that vast chemical diversity and large-scale yields can be achieved easily using commercially available hydramines. These PA samples can readily form a clear hydrogel without any external aid and show exceptionally enhanced gelation properties with a critical gelation concentration as low as 0.05 wt %. The hydrogels are highly stable against extreme pH values of 1 and 14 and a high salt concentration of 200 mM NaCl. These properties combined with the shear-thinning properties make these PA hydrogels ideal candidates for the new generation of injectable scaffolds.