Effect of Peptide Sequences on Supramolecular Interactions of Naphthaleneimide/Tripeptide Conjugates

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• 作者：Mei-Yu Yeh ; Ching-Ting Huang ; Tsung-Sheng Lai ; Fang-Yi Chen ; Nien-Tzu Chu ; Dion Tzu-Huan Tseng ; Shih-Chieh Hung ; Hsin-Chieh Lin
• 刊名：Langmuir
• 出版年：2016
• 出版时间：August 2, 2016
• 年：2016
• 卷：32
• 期：30
• 页码：7630-7638
• 全文大小：593K
• 年卷期：0
• ISSN：1520-5827

文摘

In this study, we reported a significant difference in the supramolecular hydrogelation of newly discovered NI-GFF (NI-Gly-l-Phe-l-Phe) and NI-FFG (NI-l-Phe-l-Phe-Gly) on the basis of their phase diagrams. With a small difference in the peptide chain between NI-GFF and NI-FFG, we observed a significant difference in their self-assembly properties; NI-GFF formed a stable gel at neutral pH, whereas NI-FFG did not, under the same conditions. From spectroscopic and computational studies, intermolecular π–π interactions and extended hydrogen bonding interactions might reinforce the intermolecular interactions of NI-GFF, which may facilitate the formation of the self-assembled nanostructures and the hydrogel. In addition, the aggregation-induced emission (AIE)-active NI-GFF reveals relatively good biocompatibility compared with that of NI-FFG for two commonly used cell lines, suggesting that it is a promising candidate for use as a supramolecular material in biomedical applications. Our results highlight the importance of tripeptide sequences in a self-assembling hydrogel system.