Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance

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• 作者：Qian Liu ; Weiping Wang ; Changyou Zhan ; Tianshe Yang ; Daniel S. Kohane
• 刊名：Nano Letters
• 出版年：2016
• 出版时间：July 13, 2016
• 年：2016
• 卷：16
• 期：7
• 页码：4516-4520
• 全文大小：360K
• 年卷期：0
• ISSN：1530-6992

文摘

A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet–triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm²) over a short period (5 min) using green light.