Cobalt(II)-Catalyzed Decarboxylative C–H Activation/Annulation Cascades: Regioselective Access to Isoquinolones and Isoindolinones

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• 作者：Xin-Qi Hao ; Cong Du ; Xinju Zhu ; Peng-Xiang Li ; Jia-Heng Zhang ; Jun-Long Niu ; Mao-Ping Song
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3610-3613
• 全文大小：371K
• 年卷期：0
• ISSN：1523-7052

文摘

A new cobalt(II)-catalyzed decarboxylative C–H activation/annulation of benzamides and alkynyl carboxylic acids has been described. Alkynyl carboxylic acids were first employed as the coupling partners using inexpensive Co(OAc)₂·4H₂O as the catalyst. This method enables a switchable cyclization to isoquinolones and isoindolinones with excellent selectivity. Moreover, a catalytic amount of Ag₂O was adopted as co-catalyst and O₂ (from air) as a terminal oxidant for the preparation of isoquinolones.