Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata

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• 作者：Juan Wang ; Xiao-Hui Wang ; Xiao Liu ; Jun Li ; Xiao-Ping Shi ; Yue-Lin Song ; Ke-Wu Zeng ; Le Zhang ; Peng-Fei Tu ; She-Po Shi
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3550-3553
• 全文大小：356K
• 年卷期：0
• ISSN：1523-7052

文摘

A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.