A Carbonylation Approach Toward Activation of Csp2-H and Csp3-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2-a]pyridines with Methyl Hetarenes

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• 作者：Sai Lei ; Yingying Mai ; Caijuan Yan ; Jianwen Mao ; Hua Cao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3582-3585
• 全文大小：418K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient copper-catalyzed selective cross coupling of imidazo[1,2-a]pyridines with methyl hetarenes has been reported. This transformation opened a new route to synthesize the C-3 carbonyl imidazo[1,2-a]pyridine derivative, which is a common structural motif in natural products and pharmaceuticals. ¹⁸O-labeling experiments indicated that the oxygen source of products originated from O₂.