Kinetic Resolution of Oxaziridines via Chiral Bifunctional Guanidine-Catalyzed Enantioselective α-Hydroxylation of β-Keto Esters

详细信息    查看全文

• 作者：Xiaobin Lin ; Sai Ruan ; Qian Yao ; Chengkai Yin ; Lili Lin ; Xiaoming Feng ; Xiaohua Liu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3602-3605
• 全文大小：360K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient kinetic resolution of racemic oxaziridines has been realized via catalytic asymmetric α-hydroxylation of available β-keto esters. In the presence of a chiral bifunctional guanidine catalyst, a variety of optically active oxaziridines and chiral α-hydroxy β-keto esters were generated with excellent results (ee’s of up to 99% and 97% and yields of up to 44% and 54%, respectively).