Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of α-Functionalized α,β-Unsaturated Carbonyl Substrates

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• 作者：Jian-Bo Xie ; Siqi Lin ; Shuo Qiao ; Guigen Li
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3926-3929
• 全文大小：418K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient catalytic system has been established for the asymmetric boron conjugate addition of B₂pin₂ onto α-functionalized (involving C, N, O, and Cl) α,β-unsaturated carbonyls under mild, neutral conditions involving Cu[(S)-(R)-ppfa]Cl, AgNTf₂, and alcohols. The dual additives of AgNTf₂ and alcohols were found to play crucial roles for achieving high catalytic activity and enantio- and diastereoselectivity (up to 98% ee and 70:1 dr).