Pseudoxylallemycins A–F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars

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• 作者：Huijuan Guo ; Nina B. Kreuzenbeck ; Saria Otani ; Maria Garcia-Altares ; Hans-Martin Dahse ; Christiane Weigel ; Duur K. Aanen ; Christian Hertweck ; Michael Poulsen ; Christine Beemelmanns
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3338-3341
• 全文大小：277K
• 年卷期：0
• ISSN：1523-7052

文摘

Based on fungus–fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A–F (1–6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey’s reaction. Pseudoxylallemycins B–D (2–4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A–D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.