Iron-Catalyzed Diastereoselective Synthesis of Unnatural Chiral Amino Acid Derivatives

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• 作者：Hao Zhang ; Haifang Li ; Haijun Yang ; Hua Fu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3362-3365
• 全文大小：375K
• 年卷期：0
• ISSN：1523-7052

文摘

An iron-catalyzed diastereoselective synthesis of unnatural chiral (S)-α-amino acids with γ-quaternary carbon centers has been developed. The protocol uses inexpensive iron salt as the catalyst, readily available 2-phthaloyl acrylamide and alkenes as the starting materials, and phenylsilane as the reductant, and the reactions were performed well in mixed solvent of 1,2-dichloroethane and ethylene glycol at room temperature. The method shows some advantages including simple and wide substrates, mild conditions, high diastereoselectivity, and easy workup procedures.