Metal-Free [2 + 2 + 2] Cycloaddition of Ynamides with Nitriles to Construct 2,4-Diaminopyridines

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• 作者：Jingyi Zhang ; Qingshuang Zhang ; Biao Xia ; Jie Wu ; Xiao-Na Wang ; Junbiao Chang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3390-3393
• 全文大小：383K
• 年卷期：0
• ISSN：1523-7052

文摘

We present a metal-free [2 + 2 + 2] cycloaddition of ynamides with nitriles that enables highly efficient access to 2,4-diaminopyridines. This catalytic protocol is more environmentally friendly and allows for a concomitant construction of C–C and C–N bonds between ynamides and nitriles, exhibiting excellent chemoselectivity, regioselectivity, and wide functional groups tolerance.