Silver-Free Palladium-Catalyzed sp3 and sp2 C–H Alkynylation Promoted by a 1,2,3-Triazole Amine Directing Group

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• 作者：Xiaohan Ye ; Chang Xu ; Lukasz Wojtas ; Novruz G. Akhmedov ; Hao Chen ; Xiaodong Shi
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：2970-2973
• 全文大小：436K
• 年卷期：0
• ISSN：1523-7052

文摘

Triazole amine was identified as an effective directing group in promoting C–H alkynylation under silver-free conditions. No other external oxidant was required, and the alkynylation products were received in good to excellent yields. X-ray crystallographic analysis confirmed a direct C–H activation intermediate. Other typical directing groups, including pyridine amine (PIP) and 8-aminoquinoline (QA), gave almost no reaction under identical conditions, which highlighted the unique reactivity of the triazole directing group in direct C–H functionalization.