Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration

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• 作者：Satyasheel Sharma ; Sang Hoon Han ; Yongguk Oh ; Neeraj Kumar Mishra ; Suk Hun Lee ; Joa Sub Oh ; In Su Kim
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：18
• 期：11
• 页码：2568-2571
• 全文大小：398K
• 年卷期：0
• ISSN：1523-7052

文摘

The rhodium(III)-catalyzed direct cross-coupling reaction of electron-deficient acrylamides with maleimides is described. This protocol displays broad functional group tolerance and high efficiency, which offers a new opportunity to access highly substituted succinimides. Dependent on the substituent positions of acrylamides and reaction conditions, olefin migrated products were obtained with high regio- and stereoselectivity.