Ru-Catalyzed Asymmetric Hydrogenative/Transfer Hydrogenative Desymmetrization of Meso-Epoxy Diketones

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• 作者：Yuping Hong ; Jianzhong Chen ; Zhenfeng Zhang ; Yangang Liu ; Wanbin Zhang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：18
• 期：11
• 页码：2640-2643
• 全文大小：390K
• 年卷期：0
• ISSN：1523-7052

文摘

Via a strategy of asymmetric reductive desymmetrization, chiral cis-epoxy naphthoquinols with multiple contiguous stereocenters and functional groups were synthesized with excellent enantioselectivities (96–99% ee) and diastereoselectivities (8/1–15/1). A combined asymmetric hydrogenation/transfer hydrogenation mechanism was proposed based on experimental results.